Origin and Molecular Specification of Globus Pallidus Neurons
نویسندگان
چکیده
منابع مشابه
Origin and molecular specification of globus pallidus neurons.
The mechanisms controlling the assembly of brain nuclei are poorly understood. In the forebrain, it is typically assumed that the formation of nuclei follows a similar sequence of events that in the cortex. In this structure, projection neurons are generated sequentially from common progenitor cells and migrate radially to reach their final destination, whereas interneurons are generated remote...
متن کاملElectrophysiological Characteristics of Globus Pallidus Neurons
Extracellular recordings in primates have identified two types of neurons in the external segment of the globus pallidus (GPE): high frequency pausers (HFP) and low frequency bursters (LFB). The aim of the current study was to test whether the properties of HFP and LFB neurons recorded extracellularly in the primate GPe are linked to cellular mechanisms underlying the generation of action poten...
متن کاملPre- and postsynaptic serotoninergic excitation of globus pallidus neurons.
The basal ganglia (BG) play a critical role in the pathogenesis and pathophysiology of Parkinson's disease (PD). Recent studies indicate that serotoninergic systems modulate BG activity and may be implicated in the pathophysiology and treatment of PD. The globus pallidus (GP), the rodent homologue of the primate GPe, is the main central nucleus of the basal ganglia, affecting the striatum, the ...
متن کاملActivity of neurons in monkey globus pallidus during oculomotor
29 The basal ganglia are a subcortical assembly of nuclei involved in many aspects of 30 behavior. Three of the nuclei have high firing rates and inhibitory influences: the 31 substantia nigra pars reticulata (SNr), globus pallidus interna (GPi), and globus pallidus 32 externa (GPe). The SNr contains a wide range of visual, cognitive, and motor signals that 33 have been shown to contribute to s...
متن کاملParvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.
UNLABELLED Compelling evidence suggests that pathological activity of the external globus pallidus (GPe), a nucleus in the basal ganglia, contributes to the motor symptoms of a variety of movement disorders such as Parkinson's disease. Recent studies have challenged the idea that the GPe comprises a single, homogenous population of neurons that serves as a simple relay in the indirect pathway. ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2010
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4023-09.2010